Mustangs Sweep Brevard in Basketball

first_imgThe Smoky Mountain High School Basketball teams dominated the Brevard Blue Devils Tuesday night at the New Mustangs Gym in Sylva.  The JV girls set the tempo for the evening with a 49 to 7 point blowout followed by the JV Boys  who cruised to a 65 to 47 point margin.  The Brevard Varsity girls had played the Lady Mustangs to a close game in early January in Brevard but found themselves no match for the Lady Mustangs on their home court Tuesday. Shay Tisho led all scorers with 20 points  followed by Aaliyah McCullom  with 12 points. The Mustangs put the game out of reach in the second quarter with a  19 to nine point advantage then stretched it to a 21 to nine point advantage in the third period then moved on to win 65 to 43.The Mustang Varsity Boys got six early points from Tommy Brennan and three from Tyler Waliezer to make an early statement the Mustangs would handle both the inside and the outside game as needed to set the game tempo against Brevard. The Mustangs  were on cruise control by the end of the first quarter with a 22 to nine point lead then rolled to a 25 to 10 point advantage in the second quarter to go to the dressing room with a 47 to 19 point halftime advantage.  In the third period  it is  24 to 13 point advantage  then a 16 to 8 point differential in the fourth quarter to own the night and complete the sweep with an 87 to 40 point win over Brevard. Earlier in the season the Mustangs scored 89  to 47 against Franklin and beat Tuscola 85 to 46 and 84 to 47 over Swain. Last nights 47 point win was the largest margin of victory this season for the Mustangs .The wins keep the Mustangs alive in the state rankings. Coming into Tuesday nights game the Lady Mustangs were ranked 8th in the state in the 2 – A Division.  The Mustangs Boys are currently ranked 25th in the state 2 – A division.last_img read more

January 24, 2014: Weekly Roundup of Web Design and Development Resources

first_imgThough I loved the warm weather and sunshine at WordCamp Phoenix last weekend, it’s good to be back home in Michigan. Even with wind chills bringing today’s temperature to -20 degrees Farenheit. Ouch. I hope you’re staying warm! In this week’s roundup of web design and development resources, you’ll find a free eBook on lessons learned from watching 200,000 user testing videos, discover how to create accessible user experiences, learn what’s fixed in the latest WordPress maintenance release, find out what the Net Neutrality court decision last week means for you in your everyday life, and more. Hope you find the resources helpful in your projects. Favorite Tweet”How much would it cost me to make an app with you?””The same as a car.” “What kind of car?””Exactly!”— András Velvárt (@vbandi) January 21, 2014User ExperienceLessons Learned from Watching 200,000 User Testing Videos: In their latest eBook, UserTesting.com shares the most useful lessons learned from their testing videos. Great free resource.Create your own Mac-based usability testing lab with viewing room: If you’ve been tasked with setting up a Mac-based usability testing space, you’re faced with a few challenges. Morae can’t be used since it doesn’t run on a Mac and Wirecast has issues on MacBooks. Harry Brignull explains his solution, the products used, and infrastructure changes his team implemented. 10 HTML Tags You May Not Be Using: I knew about meter and progress but didn’t know about how to use dfn. Have you used dfn in your markup?What I Found InterestingReasons to Visit Detroit: Nice shout out for the community where I live with a list of ten reasons to visit Detroit, including some of my favorites: Belle Isle and the Slow Roll.BYOD? Leaving a Job Can Mean Losing Pictures of Grandma: Yikes! Using your own device at work may mean your personal information is wiped from the device when you leave the job.Does This Ruling Mean The End of the Internet? Maybe.: What does the recent net neutrality ruling mean to you in everyday life? To name a few: it affects your privacy, ability to access whatever you want on the web (censorship) as well as providing better connectivity for rural communities. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Click to print (Opens in new window)Like this:Like Loading…RelatedWeekly Roundup of Web Design and Development News: June 9, 2017In this week’s web design and development resources roundup, you’ll learn how to build usability testing into everything you do, find out what’s new in WordPress 4.8, discover the different ways you can use viewport units, and more. If you’re new to my blog, each Friday I publish a post…In “Web design & development links”Weekly Roundup of Web Design and Development Resources: November 7, 2014The publication of a new information architecture book, accessible media player resources and demos, an application to visualize your site on different viewports, and a free online design course are a few of the resources you’ll find in this week’s web design and development roundup. If you’re new to my…In “Web design & development links”November 1, 2013: Weekly Roundup of Web Development and Design ResourcesHope you enjoyed your Halloween! We had a wet, but warm night here in Michigan. Do you have any candy left over? In this week’s roundup of web development and design resources, you’ll read about eight low-cost tools for user testing, find out why you shouldn’t fear the auto-update feature…In “Web design & development links” REMs And Viewport Measurements – Why You Shouldn’t Use Them Yet: REMs and viewport measurements make a lot of sense, but there’s a few things you should know, says Steven Bradley.So, You’re Writing A Responsive Images Script: Mat Marquis from the Filament Group discusses the issues involved with creating responsive image scripts including the benefits/pitfalls of a native solution, identifying where failures do the most damage, and whether the solution will actually work in the real world.CSS and HTML10 Tougher Tasks to Reduce Page Weight: Consider these tips from Craig Buckler to reduce page weight: replace your social sharing buttons with fat-free social buttons, use CSS3 animations instead of JavaScript, consider lazy loading for your images, and more.HTML, CSS, PSD and More: 22 Free Design Resources from December 2013: The monthly roundup of helpful design and coding resources from Noupe will help you get your projects started quickly. Note: some of the resources are free, others require registration.The section element: Updated this week by Steve Faulkner, I’m glad to read this info from the updated post With very few exceptions, section should not be used if there is no natural heading for it. andWhat we’ve been doing wrong is using section to wrap content in order to style it, or to demarcate the main content area from the nav, header, footer etc. These are jobs for div, not section. Why Don’t Screen Readers Always Read What’s on the Screen? Part 1: Punctuation and Typographic Symbols: The table included in this post is a great reference for learning what punctuation and typographic symbols the different screen readers read out loud. If I have to fill out a form to read a post you’ve tweeted, or if I have to close a pop-up on my phone, I’m not going to read the post. #ux— Sarah Chauncey (@SarahChauncey) January 22, 2014 Calling on all #browsers! Please please please please please, make your developer tools accessible! Let me keep my job! #a11y Please RT— Victor Tsaran (@vick08) January 23, 2014center_img Show Off Colors in Your Theme Demo by Using the Body Class and a Querystring: If you’re a theme developer wanting to demo theme colors by dynamically applying the body class to any page in the theme, check out this tutorial from Carrie Dils.Responsive DesignResponsive Web Development, A talk for front-end devs looking to jump into RWD: How familiar are you with responsive web development, asks Adam Moore in this Medium post as he walks through what to know to create responsive web sites and apps. I like his comment:Mobile first is more than just a way of writing code and breakpoints. Scrolling is Easier than Clicking: With analytics supporting it, and usability testing confirming it, Joshua Porter says scrolling is likely an easier gesture than clicking for people to use. People don’t have to make a decision to click something; they can continue to do what they’re already doing.AccessibilityRecap: A Web For Everyone, Accessibility as a Design Challenge: My notes from Whitney Quesenbery’s webinar earlier this week discussing the ten principles of accessible user experience.Music to Deaf Ears?: Yes, people who are deaf or hard of hearing (hoh) can enjoy and even play music. Providing sound cues [Latin music playing] as well as lyrics makes music more accessible to deaf/hoh people.There are more deaf and hard of hearing musicians than you can imagine – who can not only play, but even lead an orchestra. Microsoft Enhances Usability with Refresh of Office Web Apps: With the new flat look and better spacing, the Office Web Apps interface has caught a lot of attention. What do you think of the new “Tell Me” bar at the top of documents? A Deaf-Blind Person’s Take on Android BrailleBack: Scott, a deaf-blind person who relies almost entirely on Braille access, discusses his experience using Nexus 7 with Android 4.4. His review points out the shortcomings for email, access to books, and the difficulties faced due to Google’s lack of using the accepted standard for Braille keyboard input.WordPressWordPress 3.8.1 Released: The maintenance version includes 31 fixes for various bugs in 3.8 including the dashboard design, themes admin screen, and the one fix I was waiting for: the ability to embed tweets by copying the tweet’s URL on a separate line.The 10 Best WordPress Plugins for Security: My friend Chris Wiegman’s plugin Better WP Security leads off the list of WordPress plugins for keeping your site secure. Which one(s) do you use? WordCamp Phoenix: Day 1: My recap of the first day of WordCamp Phoenix, with key takeaways from Marc Benzakein’s workshop for DesktopServer and Joe Casabona’s presentation on responsive web design with WordPress.last_img read more

Major regulators join international panel reviewing the 737 MAX

first_imgPhoto: Boeing China will join Canada, the United Arab Emirates, Singapore and the US Federal Aviation Administration on an international panel reviewing the safety of the Boeing 737 MAX.The FAA said earlier this month that NASA would also join the international regulators on the Joint Authorities Technical Review team chaired by former US National Transportation Safety Board chairman Chris Hart.Reuters reported Tuesday that an official of Civil Aviation Administration of China had decided to send experts to be part of the FAA panel after being invited to join.Canada, the UAE and Singapore had already confirmed they would take part and an official told the news agency that regulators from Australia, EASA, Brazil, Indonesia and Ethiopia were also expected to join.READ Boeing cuts 737 productionThe cooperative approach is potentially good news for the manufacturer, which faces the threat of separate evaluations of the plane’s safety by regulators outside the US, most notably from Canada and Europe.The FAA said on April 2 that the JATR “ would conduct a comprehensive review of the certification of the automated flight control system on the Boeing 737 MAX aircraft.”READ our coverage of the Boeing crisis.“The JATR team will evaluate aspects of the 737 MAX automated flight control system, including its design and pilots’ interaction with the system, to determine its compliance with all applicable regulations and to identify future enhancements that might be needed,’’ it said.The move comes after two 737 Max aircraft, one operated by Indonesia’s Lion Air and the other by Ethiopian Airlines, crashed within five months killing 346 people.Boeing has conceded that new software added to the MAX and called MCAS was involved in both crashes but questions have also been raised about the actions of the flight crews.The US manufacturer has developed a fix for the software and expressed confidence it will prevent a repeat of the crashes.A report into the March 10 Ethiopian crash showed the aircraft was subject to repeated nose down commands and that the pilots followed at least some of the procedures highlighted by Boeing and the FAA after the Lion Air crash to render MCAS ineffective.However, there are questions about the speed at which the plane was traveling and why the pilots appear to have turned back on the stabilizer trim system and re-enabled MCAS prior to nosediving into the ground.There had been suggestions Boeing was going to present its modified software to the FAA at the beginning of April but both the manufacturer and the regulator said at the time it would not be ready for several weeks.The FAA faces a number of investigations into the certification of the plane amid allegations it was too close to Boeing.last_img read more

Tim Fisher named Director of Loss Prevention for T-Mobile USA, Inc.

first_imgBellevue, WA based T-Mobile USA, Inc. announced the appointment of Tim Fisher as their new Director of Loss Prevention. Tim joins T-Mobile after a successful career at Best Buy where he held a variety of leadership positions for both the field and corporate. Tim also held leadership positions with Target and is a member of the RILA Asset Protection Steering Committee and a member of the Board of Advisors for the LPRC.Congratulations Tim!- Sponsor –        Stay UpdatedGet critical information for loss prevention professionals, security and retail management delivered right to your inbox.  Sign up nowlast_img read more

3 Steps to Developing Your Video Surveillance System

first_imgA September 2015 survey of retailers about the current and future usage of video in their stores revealed some major frustrations and challenges. Although a detailed description of survey results can be found in “The State of Video,” the crucial findings can be distilled down to three key takeaways:The adoption of modern video capabilities has been low despite the significantly lower costs of ownership of a vastly improved technology.
While the number of retailers with central monitoring stations has increased in the last five years, in 60 percent of those retailers, they are actively monitoring less than 10 percent of their stores.Finally, and despite the industry buzz, video surveilleance cameras today in retail remains predominantly a tool to guard assets and people, where the accountability for video surveillance system strategy predominantly rests with the asset protection team.So how do you, as a frustrated asset protection leader, move your organization forward and more fully realize the benefits of advanced video technology? Based on our experience at leading change, we propose three next steps that you could undertake—steps that could be the building blocks for a new video surveillance system strategy.Step 1. Complete a Strengths, Weaknesses, Opportunities, and Threats (SWOT) AnalysisThe SWOT tool is possibly the tool most often used by management the world over in the development of new strategies. To use it correctly, the strengths and weaknesses should be those that are internal to the organization. Opportunities and threats should refer to the trends, changes, and events happening outside of your organization that will impact your strategy.- Sponsor – Before any SWOT exercise is undertaken, two things need to happen. The first is a period of data collection, and the second is identifying and then inviting all the most relevant stakeholders to participate in the SWOT exercise, potentially as part of an offsite meeting.In terms of data collection, here would be some good data to collect prior to undertaking the SWOT exercise.Technology audit—Find out what video equipment is in what stores, in what working order, and so forth.Total cost of ownership—Identify all the current costs of video, capital, depreciation, maintenance, new-for-old replacement, hours in store spent monitoring, and so forth.Internal perceptions—Leverage free online survey tools such as SurveyMonkey to complete an organization-wide survey. Create a set of questions to understand the current perceptions of video amongst all the stakeholders, their perception of the benefits of its use today, and their interest in different use cases for video.External benchmarking—Leverage industry surveys such as the RILA survey just summarized and the generosity of your peers who have embarked on a new video strategy to become better informed on how others outside of your organization are responding to the video opportunity.Technology now and then—Learn from the vendor community, academics, and industry experts about their current and future visions of video technology in retail and the implications for your potential strategies.With regard to stakeholders, involving all the relevant stakeholders from the start of the process will do more to deliver change than possibly anything else you can or will ever do. The failure to include and involve the right stakeholders at the very beginning of a large change project—and this qualifies as such—has been the downfall of many a fine and elegant video surveillance system strategy.A stakeholder should be defined as anyone inside and outside the organization who will be impacted by change and/or will be required to act to enable successful change. In the case of retail, the internal stakeholders beyond asset protection would include but are not limited to store operations, buildings maintenance, store design, merchandising, information technology, marketing, legal, and finance. Outside stakeholders would include but are not limited to the current video providers, third-party security guard companies, and consumer privacy groups.Clearly, discretion and judgment would be needed on how and when to involve the different external stakeholders, but for the internal groups where the degree of possible change and acceptance of the strategy will be critical to the success, they should be invited to participate in the SWOT exercise.For the timing of the exercise, you should plan for at least a day, with the first part of the day dedicated to providing the group a full grounding on all the data collected, possibly with an external speaker to bring the outside in and to act as a benchmark. In the afternoon, smaller cross-functional groups of three to four people should create their own SWOTs. Each group would then report back, and one consolidated SWOT would be created to represent the combined wisdom of the entire group. By going off site, you signal that a degree of importance has been placed to this opportunity for change while also having the benefit of ensuring that you get everyone’s full attention with no distractions.With the SWOT completed, the actions should be identified to leverage strengths, address weaknesses, exploit external opportunities, and mitigate any external risks. These will form the substance of your strategy.Perhaps the most important part of a good SWOT analysis is honest and candid input and feedback. If the SWOT is performed by stakeholders who only share what they think upper management wants to hear, the purpose of the exercise is defeated. Only honest, and sometimes blunt, feedback will help move the organization forward.Step 2. Align the Organization to a Five-Year End-State VisionWhen you are building something new, advisors suggest that you start with the end in mind, and so it should be with your surveillance video strategy. The deeper, richer, and more specific you can be about your end state, the easier it will be for your organization to align to it and get behind it.The creation of the end-state vision can be a natural follow-on exercise from the SWOT exercise, and the involvement of all stakeholders in its creation will greatly help the eventual adoption across the organization.To create the vision, stakeholders will need to have access to data on current costs, installations, user surveys, benchmarking, and future technology choices. The clearer a vision is, the easier it will be for people to want to support it. Clarity can be gained by using direct statements and visuals that may help support those statements. Avoid using jargon, buzzwords, or phrases like “optimize the value proposition for the enterprise,” as it will cloud your vision.Just as important as creating a clear vision is ensuring that the vision articulates why video is important. By just stating what video does, the organization may not truly believe or understand why it is important. This statement shouldn’t be as simple as “Video is used to watch bad guys,” but rather something that catches the attention of a manager because it is profound and clearly matters.Below are some example statements for your video surveillance system strategy, which could all start with “In 2021, our video capability will…”:Transform how we operate by leveraging video as a force multiplier.Allow for the safest environments possible for our shoppers and associates.Create unique insights that help us grow sales, reduce costs, and simplify our operations.Deliver a more efficient staffing model by leveraging central stations and remote viewing.Be viewed as a technology for the entire company, instead of just for asset protection.These are example statements that will need further detail and belief if they are to withstand the curiosity and the questioning of senior executives. How will video make stores safer and more secure? How will video in the future increase sales? Be ready to articulate those responses with clarity and confidence.Step 3. Develop Meaningful Pilots to Prove the Business CaseIt can be tempting to take up offers from vendors to trial the latest video technology in a store or two at near-zero cost. But this misses the real point about video or indeed any other technology, which is to understand how technology could help existing tasks be better, faster, simpler, and less expensive. Or how could technology enable new work processes that could deliver new, new to the world, business benefits?By way of example, we know that video can be set up to alert those in the store, via mobile devices, of unusual activity in the locations of products targeted by organized retail thieves. How would we set up a meaningful pilot to prove the business case? Here are some thoughts.First, and this may seem a bit back-to-front to many, but before any technology is thrown at the problem, the activity system, the work process, and the behaviors and new skills that need to be put in place should be defined. Only when these are defined can you start to know the specifications and functionalities required of the technology. But more importantly, it is only when you can know the whats, hows, whens, and by whoms, can you get a sense of the likelihood of this use case being a success.Second, and after all the above detail has been thrashed out, the organized retail crime (ORC) event monitoring activity system and the alerting capability technology choices should be tested for reliability, accuracy, and applicability. Do the alerts always signal ORC activity? Are these ORC events communicated to those in the store in a way that can help them act on them at the right time? Are store associates comfortable with approaching potential ORC thieves?Third, and once confidence in this ORC use case has been established, then an experiment should be designed to test the actual impact of these ORC alerts by setting up some stores to receive the ORC alerts and others, even though the ORC alerts would be created by the system, not to receive the ORC alerts.At this stage, consideration could be given as to whether communication would be placed in the stores to alert would-be thieves to the new capability. If this is of interest, then potentially the impact could be measured by adding a second set of test stores.With this completed test design, the changes in the number of ORC events in the test store before and after the intervention, and relative to the control stores, could be measured. If a meaningful difference is found in the change in the number of ORC events in the test stores with and without communication, then because you have isolated the impact of the communication, you could potentially learn the extent that collusion is impacting ORC.For store selection, the test and control stores should be matched in terms of risk and shopper profiles to ensure that the results have credibility with management. So if the intervention is only planned for the highest-risk stores, then only select high-risk control and test stores. If there is an idea for a chain-wide deployment, then choose a cross section of stores across the risk spectrum.Choosing the right hot product category to test the capability will be important. Your choices should consider the extent to which you believe organized thieves are targeting the product, the location of that category in the store, and proximity to staff. Finally, you may want to consider the potential impact on sales of a better theft deterrent intervention such as real-time alerts. Would the presence of better intervention help the store feel more confident to place items on open sales and thus increase sales?Good examples of possible hot product categories could be spirits, infant formula, or family planning, all of which are frequently locked up in stores or only have a minimal presence of product on display leading to shelf out of stocks.Finally, you need to define the hard and soft metrics for the test. The hard business measures could be sales, shrink, and on-shelf availability. The softer measures could be store manager and associate interviews and shopper intercepts.While this use case is one that benefits the asset protection team and the merchant responsible for the chosen category, other use cases worth considering for pilots could include:Virtual video visits supplementing in-person visits,EAS alarm/video integration creating video bookmarks for each alarm,Lighting/video integration saving energy expense by checking on overnight lighting,Time studies using remote video to measure processes instead of onsite people,Shopper insights to measure traffic, dwell time, and conversion rates through video.Now, Your Leadership Is RequiredVideo surveillance system technology can be a real change catalyst for the asset protection organization. It not only can enhance operations and improve results, but it can also create an avenue for asset protection to better partner with the rest of the retail organization. Asset protection always seeks to enhance its influence in the organization and is always looking to have a seat at the table when it comes to making big decisions. What better way to create credibility and partnership than to offer others access to a technology that many would benefit from?For detailed survey results, check out the full article, “The State of Video,” which was originally published in LP Magazine in 2016. This excerpt was updated August 22, 2017. Stay UpdatedGet critical information for loss prevention professionals, security and retail management delivered right to your inbox.  Sign up nowlast_img read more

New study shows promise of innovative strategy against HER2driven lung cancers

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 8 2018The HER2 gene is a well-known driver of breast cancer, where changes in this gene are found in about 1-in-5 cases of the disease. HER2 also contributes to about 3 percent of lung cancers, representing about 6,500 patients per year. But while drugs like trastuzumab and lapatinib have proven effective in silencing the action of HER2 in breast cancer, there are currently no approved HER2-targeted therapies for the treatment of lung cancer.Now, a University of Colorado Cancer Center study presented at the 30th annual EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics shows the promise of an innovative new strategy against HER2-driven lung cancers (with EGFR involvement, which is also a well-known driver of lung cancer). Tarloxotinib, a potent HER2/EGFR inhibitor, is unique in that the drug only becomes active in low-oxygen conditions, such as those commonly found in tumor tissue. By pairing a potent HER2/EGFR inhibitor with a targeting mechanism specific to tumors, researchers show that tarloxotinib is far more active against lung cancer cell lines than even the most successful existing HER2/EGFR inhibitors, with minimal effect on surrounding, healthy tissues.”We are very excited about this drug. When it’s near healthy cells, it’s inactive; when it’s near tumor cells, it’s very active. This could provide a new therapeutic approach for patients with HER2 lung cancer,” says Robert C. Doebele, MD, PhD, director of the CU Cancer Center Thoracic Oncology Research Initiative. Dr. Doebele is a co-founder of Rain Therapeutics Inc., a clinical stage biotechnology company developing tarloxotinib as its lead drug candidate.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskResearchers identify potential drug target for multiple cancer typesAdding immunotherapy after initial treatment improves survival in metastatic NSCLC patientsTarloxotinib is one in a class of anti-cancer agents known as “prodrugs,” in which inactive molecules are transformed by specific conditions inside the body into active molecules. In the case of tarloxotinib, oxygen molecules scavenge electrons from the prodrug to keep it inactive. In the absence of oxygen, tarloxotinib fractures into its active form.The current study shows that in healthy, high-oxygen tissues, it takes about an hour for the body to clear half of any administered molecules of tarloxotinib; in low-oxygen tumor tissues, the same clearance takes about 80 hours. This makes tarloxotinib about 50 times more active in low-oxygen conditions than it is in normal-oxygen conditions. And low-oxygen conditions, aka “hypoxia,” are a hallmark of cancer, in which the growth of tumor tissue often outpaces the growth of blood vessels needed to supply the tumor with oxygen.”The problem is that the concentration of HER2/EGFR inhibitor needed to affect HER2/EGFR lung cancer is so high that these drugs have come with too many side effects to be clinically useful. We hope that our approach with this prodrug will solve that problem, delivering the HER2/EGFR inhibitor where it’s needed without compromising function in healthy tissues,” says Adriana Estrada-Bernal, PhD, the study’s first author.At noon (GMT) on November 13, the group will present data describing the therapeutic effect of tarloxotinib on mouse models of lung cancer. Collaborators at the University of Auckland will present the following additional data: Source:http://www.ucdenver.edu/last_img read more

Amount of compensation for injured workers depends on type of impairment rating

Reviewed by James Ives, M.Psych. (Editor)Dec 14 2018If you experience an injury at work, the amount of compensation you receive depends on which impairment rating system is used, according to research from McMaster University and the Netherlands.The American Medical Association (AMA) Guides to the Evaluation of Permanent Impairment is used in workers’ compensation systems, federal systems, automobile accidents and personal injury cases to rate impairment.However, a comparison of a group of injured workers assessed using the two most recent editions of the AMA guides revealed that usage of the sixth edition resulted in significantly lower impairment ratings than the fifth edition.The findings were published today in the Journal of Occupational and Environmental Medicine.”Our study shows your impairment rating will depend on the version of the AMA guides that you are assessed with,” said Jason Busse, first author and an associate professor of anesthesia at McMaster.”The difference in impairment rating is likely due to the fact that when these guides first came out, they were focused on pain and range of motion, and they have increasingly moved to more direct measures of function.Related StoriesAre Chronic Pain Relief Drugs for Children Effective?AMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyResearch sheds light on sun-induced DNA damage and repair”For example, in an earlier guide they may have measured whether a person could lift their arm above their head without discomfort, but now they look at whether the person could put a box on a shelf.”Researchers used data from a consecutive sample of 249 injured workers referred for an independent evaluation at the Orthopedisch Expertise Centrum Amsterdam between 2011 and 2012.The results showed the median whole person impairment rating was seven per cent for 131 claimants assessed with the fifth edition of the AMA guides, and four per cent for 118 claimants assessed with the sixth edition.”Because all assessors in the Netherlands switched from the fifth to the sixth edition at the same time, we were able to study two large cohorts of patients with similar injuries and explore the impact on impairment ratings,” said Busse, who is also a researcher with the Michael G. DeGroote Institute for Pain Research and Care.The other major finding of the study was considerable inconsistency of AMA Guides editions used by workers’ compensation boards across North America.”There was a tremendous variability in the edition that North American compensation boards are using,” Busse said. “The most recent version, which was the sixth, was published in 2007. Yet, for example, we have the largest compensation board in Canada, which is in Ontario, using the third revised version which came out in 1991.”Busse said he recommends consistency across compensation boards.”Workers’ compensation boards should standardize impairment rating systems so that everyone is gauged on the same scale,” he said. “If we believe that more recent editions of the AMA guides do a better job of quantifying impairment, why is it that so many Boards are using earlier versions?”Source: https://www.mcmaster.ca/ read more

Trojan horse drug shows promise for untreatable cancers

first_imgThe researchers saw tumors shrink or stop growing in 27.0% of bladder cancer cases, 26.5% of cervical, 14% ovarian, 13% esophageal, 13% non-small cell lung and 7% endometrial.The treatment responses lasted for an average of 5.7 months and, in some cases, for up to 9.5 months.“Our early study shows that it has the potential to treat a large number of different types of cancer, and particularly some of those with very poor survival rates,” says de Bono.The results have been so successful that the drug is now being tested in trials of other cancers including pancreatic, bowel and head and neck. It is also being tested as a second-line treatment for cervical cancer in a phase II trial.“We have already begun additional trials of this new drug in different tumor types and as a second-line treatment for cervical cancer, where response rates were particularly high. We are also developing a test to pick out the patients most likely to respond,” says de Bono.Chief Executive of The Institute of Cancer Research, Paul Workman says it is exciting to see the potential this drug has shown across a range of difficult-to-treat cancers: I look forward to seeing it progress in the clinic and hope it can benefit patients who currently have run out of treatment options.”Paul Workman, Chief Executive, ICR What is so exciting about this treatment is that its mechanism of action is completely novel – it acts like a Trojan horse to sneak into cancer cells and kill them from the inside.”Johann de Bono, Lead Author Sources:https://www.icr.ac.uk/news-archive/new-trojan-horse-cancer-treatment-shows-early-promise-in-multiple-tumour-typeshttps://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30859-3/fulltext By Sally Robertson, B.Sc.Feb 8 2019Reviewed by Kate Anderton, B.Sc. (Editor)A new cancer drug that uses a ‘Trojan horse’ approach to enter cancer cells and destroy them from within has shown promising results across six different forms of cancer.Dmitriy Rybin | ShutterstockThe new treatment succeeded in significantly improving survival among a minority of patients with cancers that other drugs had failed to treat.A team of researchers from The Institute of Cancer Research, London and The Royal Marsden NHS Foundation Trust led a phase I/II clinical trial that included nearly 150 patients with different types of cancers that had stopped responding to standard treatments.As reported in The Lancet Oncology, the new treatment either shrank or stopped tumors growing in one-quarter of patients with cervical or bladder cancer and almost 15% of patients with lung or ovary cancer.The new drug is made up on an antibody with a cancer-killing agent attached to its tail end. The antibody binds to receptors present on the surface of cancer cells and then draws the chemotherapy agent inside.last_img read more

Colorectal cancer diagnosed at early age is distinct from that in older

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 12 2019New research indicates that colorectal cancer diagnosed at an early age has clinical and genetic features that are different from those seen in traditional colorectal cancer diagnosed later in life. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study also revealed certain unique features in especially young patients and those with predisposing conditions.Although incidence and mortality rates of colorectal cancer have fallen in patients aged 50 years and older, early-onset colorectal cancer rates have been increasing over the past two decades. To look for differences between early-onset and late-onset colorectal cancer, investigators at The University of Texas MD Anderson Cancer Center in Houston analyzed information on more than 36,000 colorectal cancer patients.Related StoriesNew protein target for deadly ovarian cancerResearchers use AI to develop early gastric cancer endoscopic diagnosis systemHow cell-free DNA can be targeted to prevent spread of tumorsThe researchers found that younger patients were more likely to have certain genetic mutations and certain subtypes of colorectal cancer than older patients. Also, among patients with early-onset colorectal cancer, very young patients (aged 18-29 years) were unique from older patients (aged 30-49 years) in terms of the clinical and genetic features of their cancer. Likewise, patients with early-onset colorectal cancer who had predisposing conditions, such as inflammatory bowel disease, had different clinical and genetic characteristics compared with patients without predisposing conditions.”We need to appreciate that there are unique biologic subtypes within young patients that may affect how their cancers behave and may require a personalized approach to treatment,” said senior author Jonathan Loree, MD. “Going forward, special clinical consideration should be given to, and further scientific investigations should be performed for, both very young patients with colorectal cancer and those with predisposing medical conditions.”March is Colorectal Cancer Awareness Month.Source: https://newsroom.wiley.com/press-release/cancer/colorectal-cancer-patients-early-onset-distinct-older-patientslast_img read more

Study reveals older womens perceptions of wearable and smart home activity sensors

first_img Source:https://www.cuanschutz.edu/ Reviewed by James Ives, M.Psych. (Editor)Apr 30 2019A study conducted by Assistant Professor Blaine Reeder, PhD, and co-authored by Catherine Jankowski, PhD, at the University of Colorado College of Nursing on older women’s perception of technology found that more active older adult women prefer wearable sensors for themselves and smart home sensors for their older parents.Published in Informatics for Health and Social Care, the study titled “Older Women’s Perceptions of Wearable and Smart Home Activity Sensors” included ten women with an average age of 65 years. The study aimed to characterize perceptions of wearable and smart home technologies for older women. Consumer-grade wearable activity monitors include fitness trackers such as Fitbit and Yamax CW700 as well as smart watches with accelerator sensors; smart home technologies include sensors installed in the residential environment that allow for passive monitoring of health. Home sensors include bed and chair pressure sensors, activity sensors, video sensors, door and window sensors, and leak detection sensors.Related StoriesTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTNursing home care prices rise faster than other medical care and consumer pricesComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous research”Our findings that younger, more active older adult women prefer wearable sensors for themselves and smart home sensors for their parents is important to tailoring technology research for independent aging,” said Reeder. Dr. Reeder conducts informatics research to connect the contexts of personal health and public health with a focus on three areas: aging in place, organizational information systems, and research tools.”Given the greater number of women who will live into old age and their specific age-related risks, such as high-risk for fracture due to low bone mass, there is a need to identify approaches that help women to age independently. Sensor-based technologies show promise, but their acceptability with older adult women must be understood to promote adoption into daily life,” said Reeder.This study showed that in general, wearable sensors were perceived as more useful than smart home sensors because most participants had high levels of activities outside their homes. In addition, both technologies were acceptable for personal activity data collection, and participants had few concerns about data sharing.Technology perceptions were assessed during a larger pilot study led by Dr. Jankowski to evaluate technology measurements of jumping activity, which led to the funding of her current R01 on DHEA and Musculoskeletal Adaptations to Exercise in Older Women.last_img read more