Tag: 杭州桑拿

first_imgA widely used diabetes drug dramatically boosted the potency of platinum-based cancer drugs when administered together to a variety of cancer cell lines and to mice with tumors, report scientists from Harvard-affiliated Dana-Farber Cancer Institute.Combining a platinum chemotherapy agent with the diabetes drug rosiglitazone halted or shrank mouse tumors as much as three times more effectively than either of the drugs given alone, according to the researchers’ article in the May issue of Cancer Cell.If pairing the drugs has the same synergistic effect in humans, the researchers say, it could improve control of ovarian, lung, and other cancers routinely treated with platinum-based chemotherapy, to which tumors eventually become resistant. Moreover, the experiments suggest the combination might extend the use of platinum drugs to other cancers where they haven’t previously been shown to be effective.“There’s still a huge gulf between these experiments and human cancers,” said Bruce Spiegelman, senior author of the report and professor of cell biology at Harvard Medical School (HMS). “But it’s worked in every animal model of cancer we’ve looked at, and I think there’s a fair chance it will help people.”Dana-Farber researchers are already drawing up plans for initial clinical trials, which could begin sometime this year.“We really see a way forward here to improve the chemotherapy’s effectiveness for multiple forms of cancer,” said HMS Associate Professor of Medicine George Demetri, a Dana-Farber researcher who is preparing a proposal for a pilot study of rosiglitazone and platinum chemotherapy drugs in lung and ovarian cancer and sarcomas.If a pilot study shows promising activity, the combination would need to be compared with standard chemotherapy in larger Phase II and Phase III trials involving many hundreds of patients.Rosiglitazone, sold under the name Avandia, enhances insulin receptors’ sensitivity in people with diabetes whose pancreas secretes too little insulin. It was approved in 1999 for use by patients with type 2 diabetes to help control blood sugar levels. An estimated 5 million people in the United States take Avandia or a similar drug, pioglitazone, which is sold as Actos.Both drugs work by activating PPAR-gamma, a transcription factor that functions as a master regulator of fat development in the body, a function discovered in the Spiegelman lab in 1994. Spiegelman and others observed that certain PPAR-gamma-activating compounds, called PPAR-gamma ligands, caused cancer cells to stop growing and become more mature, or differentiated. Therefore, Spiegelman and others felt it was a logical step to try PPAR-gamma ligands as cancer treatment, but several small clinical trials found rosiglitazone alone was ineffective against several cancer types.Despite this setback, and because rosiglitazone was well-tolerated by patients compared with tolerance for standard cancer drugs, Dana-Farber researchers believed it was worthwhile to try it and similar PPAR-gamma ligands in a different context, said HMS instructor Geoffrey Girnun, a researcher in Spiegelman’s laboratory and lead author of the Cancer Cell report. “After discussing it with other Dana-Farber researchers, we decided to try these agents in combination with platinum-based drugs, and in several different cell lines, we saw positive results,” said Girnun.In addition to rosiglitazone, the scientists tested pioglitazone and an experimental compound made by GlaxoSmithKline, combining each of them with cisplatin, carboplatin, and oxalyplatin — all commonly used chemotherapy drugs that destroy cancer cells by damaging their DNA.When non-small-cell lung cancer cell lines were treated with rosiglitazone alone, there was no effect on growth. Carboplatin alone reduced growth of the cancer cells by about 60 percent. But when both drugs were administered, cell growth was reduced by 80 percent. The drugs were also tested individually and together on ovarian cancer cell lines that normally are resistant to chemotherapy — and proved capable of reducing growth of the cancer cells by 90 percent. Even when applied to colon cancer cells, a type of cancer not usually treated with platinum drugs, rosiglitazone and carboplatin lowered the growth rate by 70 percent. (Rosizitaglone did not show the same positive effect when paired with oxalyplatin.)The drug combination also had striking growth-suppressing results when given to mice with human lung and ovarian tumors implanted under their skin and in mice that had received a chemical that causes them to develop colon cancer.The experiments showed that the PPAR-gamma ligands suppressed the activity of metallothioneine genes, which are believed to trigger the development of cancer cells’ resistance to platinum chemotherapy.“Our finding that PPAR-gamma activation dramatically increases the efficacy of carboplatin, potentially causing tumor stasis or even tumor shrinkage, could represent a significant advance in chemotherapy,” the researchers wrote.last_img read more

first_imgCOOPERSTOWN, N.Y. | Frank Thomas choked back tears, Joe Torre apologized for leaving people out of his speech and Tony La Russa said he felt uneasy.Being enshrined in the Hall of Fame can have those effects, even on the greats.Thomas, pitchers Tom Glavine and Greg Maddux, and managers Bobby Cox, Torre and La Russa were inducted into the baseball shrine Sunday, and all paid special tribute to their families before an adoring crowd of nearly 50,000.“I’m speechless. Thanks for having me in your club,” Thomas said, getting emotional as he remembered his late father. “Frank Sr., I know you’re watching. Without you, I know 100 percent I wouldn’t be here in Cooperstown today. You always preached to me, ‘You can be someone special if you really work at it.’ I took that to heart, Pop.”“Mom, I thank you for all the motherly love and support. I know it wasn’t easy.”The 46-year old Thomas, the first player elected to the Hall who spent more than half of his time as a designated hitter, batted .301 with 521 home runs and 1,704 RBIs in a 19-year career mostly with the Chicago White Sox. He’s the only player in major league history to log seven straight seasons with a .300 average, 20 homers, 100 RBIs and 100 walks.Ever the diplomat as a manager, Torre somehow managed to assuage the most demanding of owners in George Steinbrenner, maintaining his coolness amid all the Bronx craziness while keeping all those egos in check after taking over in 1996. The result: 10 division titles, six AL pennants and four World Series triumphs in 12 years as he helped restore the luster to baseball’s most successful franchise and resurrected his own career after three firings.Torre, the only man to amass more than 2,000 hits (2,342) and win more than 2,000 games as a manager, was last to speak, and in closing delivered a familiar message.“Baseball is a game of life. It’s not perfect, but it feels like it is,” said the 74-year-old Torre, who apologized afterward for forgetting to include the Steinbrenner family in his speech. “That’s the magic of it. We are responsible for giving it the respect it deserves. Our sport is part of the American soul, and it’s ours to borrow — just for a while.”“If all of us who love baseball and are doing our jobs, then those who get the game from us will be as proud to be a part of it as we were. And we are. This game is a gift, and I am humbled, very humbled, to accept its greatest honor.”The day was a reunion of sorts for the city of Atlanta. Glavine, Maddux and Cox were part of a remarkable run of success by the Braves. They won an unprecedented 14 straight division titles and made 15 playoff appearances, winning the city’s lone major professional sports title.“I’m truly humbled to stand here before you,” Cox said. “To Tom Glavine and Greg Maddux, and I have to mention the third member of the big three — John Smoltz — I can honestly say I would not be standing here if it weren’t for you guys.”Smoltz, part of the MLB Network telecast of the event and eligible for induction next year, flashed a smile in return for the compliment.Glavine started when the Braves won Game 6 to clinch the 1995 World Series, pitching one-hit ball over eight innings in a 1-0 victory over Cleveland. And the slender lefty was one of those rare athletes, drafted by the Braves and the Los Angeles Kings of the National Hockey League.“I had a difficult choice to make, and as a left-handed pitcher I thought that was the thing that would set me apart and make baseball the smartest decision,” Glavine said. “Of course, I always wondered what would have happened had I taken up hockey.”“In my mind, since I was drafted ahead of two Hall of Famers in Luc Robitaille and Brett Hull, that obviously means I would have been a Hall of Famer in hockey, too,” Glavine chuckled as the crowd cheered. “But I’m positive I made the right choice.”The 48-year-old Maddux went 355-227 with a career ERA of 3.16 in 23 seasons with the Braves, Cubs, Padres and Dodgers and ranks eighth on the career wins list. He won four straight Cy Young Awards in the 1990s and won 15 or more games for 17 straight seasons with his pinpoint control.“I spent 12 years in Chicago, 11 in Atlanta, and both places are very special,” Maddux said. “Without the experiences in both cities, I would not be standing here today.”La Russa, who ranks third in career victories as a manager with 2,728, behind only Connie Mack and John McGraw, was chosen manager of the year four times and won 12 division titles, six pennants and three World Series titles in stints with the White Sox, Oakland A’s and St. Louis Cardinals.La Russa spoke from the heart. There was no written speech.“It’s uncomfortable because I didn’t make it as a player. Not even close,” said La Russa, who made his big league debut as a teenage infielder with the 1963 Kansas City Athletics and appeared in just 132 games over six seasons, hitting .199 with no home runs. “Since December, I have not been comfortable with it. There’s no way to mention everybody, and that bothers me.”“From managing parts of two years in the minor leagues, after thinking about all the other young managers who paid a lot of dues in the minor leagues and I get a chance and then I go into the big leagues with three organizations,” he said. “All that equates to me is I’m very, very fortunate. I’ve never put my arms around the fact that being really lucky is a Hall of Fame credential.”Follow Kekis on Twitter at https://www.twitter.com/Greek1947last_img read more

first_imgChelsea boss Lampard: Mourinho had a go after Man Utd defeatby Paul Vegas7 days agoSend to a friendShare the loveChelsea boss Frank Lampard has revealed Jose Mourinho “had a little go” at him following their opening day defeat at Manchester United.The Blues got their campaign off to a miserable start with a 4-0 defeat at Old Trafford, which marked Lampard’s first competitive game at the helm.Speaking to talkSPORT, Lampard said: “With Jose we would have texts from time to time. We had some at the start of the season around the United game where he had a little go!” Lampard, who spent a period of time working for BT Sport, accepts that it is nothing personal.”It’s all good,” he added. “I’ve sat in the punditry chair for a year so I understand the need to say things so I’m certainly not going to bang on too much. In terms of him, yeah we have a relationship.” About the authorPaul VegasShare the loveHave your saylast_img read more

first_imgTarik Black lists his top ten colleges on Twitter.tarik black top ten twitterFour-star wide receiver recruit Tarik Black, a 6-foot-3, 185-pound product of Chesire, Connecticut, has offers from dozens of college football programs ahead of the 2017 season. Sunday night, he narrowed his list down to 10. Black’s list includes one SEC school (Alabama), two Pac-12 schools (UCLA, Arizona State), three ACC schools (Duke, Miami, Virginia Tech) and four Big Ten schools (Maryland, Michigan, Michigan State, Rutgers).Thankful for every Opportunity #Top10 pic.twitter.com/K5UfbYt29X— TJ Black (@LetmeRockk_) December 7, 2015You can check out Black’s highlight reel here.last_img read more

first_imgUCF flag flies before AAC championship game.ORLANDO, FL – DECEMBER 2: A UCF Knights spirit team member waves the flag after a score in the third quarter of the ACC Championship against the Memphis Tigers at Spectrum Stadium on December 2, 2017 in Orlando, Florida. (Photo by Julio Aguilar/Getty Images)Fort Lauderdale wide receiver Dredrick Snelson had a wild recruitment, but in the end, he will be staying close to home with the UCF Knights. Snelson, a one time Minnesota commit, chose UCF over finalists Maryland and Penn State. He also reportedly had offers from Alabama, Florida, Florida State, Miami, and numerous others.#Flanagan HS (FL) 2016 WR Dredrick Snelson (@D_Snelson2) signs LOI with the #UCF #Knights pic.twitter.com/iIInG76D5k— Sleeper Athletes (@SleeperAthletes) February 3, 2016Snelson is a four-star player according to ESPN and Rivals. ESPN ranks him as the No. 20 wide receiver in the class.last_img read more

first_img The Real Estate Board (REB) will be hosting a public forum on Thursday (September 7) on its new Continuing Professional Development (CPD) requirement for real estate professionals. Story Highlights Chief Executive Officer (CEO) of the board, Sandra Watson-Garrick, told JIS NEWS that the forum is to provide information about the changes in the industry as well as the new skills and competencies required. The event will take place at the Girl Guide Association of Jamaica headquarters located at 2 Waterloo Road in Kingston (beside Devon House) and is targeting persons involved in the Real Estate profession in Jamaica. The Real Estate Board (REB) will be hosting a public forum on Thursday (September 7) on its new Continuing Professional Development (CPD) requirement for real estate professionals.The event will take place at the Girl Guide Association of Jamaica headquarters located at 2 Waterloo Road in Kingston (beside Devon House) and is targeting persons involved in the Real Estate profession in Jamaica.Chief Executive Officer (CEO) of the board, Sandra Watson-Garrick, told JIS NEWS that the forum is to provide information about the changes in the industry as well as the new skills and competencies required.“Changes will happen in any industry and (professionals) have to keep abreast of those changes.  Sometimes, if you’re not knowledgeable, you will pass on the wrong information to the public,” she told JIS News.“So, the whole idea of the workshop is to make the industry understand why we have to go the route of professional development. How they would sell real estate in the past they are not doing that anymore. Now you are marketing through social media. You are also doing so within a context of higher security risks,” she noted further.The Real Estate Board introduced the CPD courses through its Real Estate Training Institute in May 2017.These courses are being offered in preparation for the 2018/2019 licencing year, which starts April 1, 2018.Practitioners will be required to do at least 20 hours of such courses every two years, which will consist of mandatory and optional courses for dealers, salesmen and developers.Mandatory courses will contribute eight hours while the remaining 12 hours will come from optional courses.Mrs. Watson-Garrick is encouraging practitioners to register early for the training courses.She said the board must see some evidence that training has started in order to renew licences for 2018/2019.For further information persons may contact the Real Estate Board/Commission of Strata Corporations at 24 Trafalgar Road, Kingston 10, call 926-9746 -9, or visit their website at www.reb.gov.jm.last_img read more

first_imgMedical ID Marketplace by Hope Paige, the foremost designer of fashionable medical accessories, has teamed up with eight celebrities to create customized bracelets in order to benefit a variety of charities.Their designs will also serve to raise awareness for illnesses such as epilepsy, cancer, diabetes and food allergies. These bracelets are available for purchase on the Medical ID Marketplace website.The following celebrities and charities are participating in this campaign: • Melissa Joan Hart – St. Jude Children’s Research Hospital • Kimora Lee Simmons – Juvenile Diabetes Research Foundation (JDRF) • Leeza Gibbons – Leeza’s Place • Misty May Treanor – Breastcancer.org • Dot Marie Jones – American Cancer Society • Greg Grunberg – TalkAboutIt.org • Meat Loaf – The Painted Turtle • Kenton Duty – The Food Allergy and Anaphylaxis Network (FAAN)Each celebrity has partnered with a charity of their choice based on causes they strongly support and feel are aligned with their philanthropic efforts. 100 percent of profits from each bracelet sale will go towards their corresponding charity. The women’s bracelets retail for $39.99, while the men’s bracelets retail for $39.95.“We are thrilled that these celebrities have come on board to support these amazing causes as well as help us to raise awareness about the importance of wearing a medical id,” said Shelly Fisher, CEO and Founder of Medical ID Marketplace by Hope Paige. “This campaign comes at a perfect time, as these bracelets would make for a great holiday gift for anyone wanting to put health and safety first while remaining fashionable and trendy.”While each celebrity has a different reason for participating, they all have an inspiring story to share. Visit www.hopepaige.com to browse the bracelets and find out why each celebrity recognizes the importance of wearing a medical id.Source:PR Newswirelast_img read more

first_imgBALURGHAT: Tension gripped Kushmandi’s Maligaon area on Saturday morning after the body of a local TMC worker was found around 5 km away from his residence by the locals. Murder is being suspected.The deceased TMC worker has been identified as Harihar Das (50), a resident of Panchhata. Police have initiated an investigation. No arrests have been made so far. Das had gone missing since Friday afternoon. As he had not returned till late in the evening, his family members initiated a search operation but in vain. Also Read – Bengal family worships Muslim girl as Goddess Durga in Kumari PujaIn the morning, the locals discovered his body lying beside a pond with traces of rampant beating on the head. The stick was also found beside the body. Police rushed to the spot after being intimated and faced public demonstration as he was a popular face of the party there. Police, however, managed to recover his body after positive assurances. Later it was sent for postmortem to Balurghat district hospital. A local, named Bachchu Das, said: “I discovered the body in the morning while crossing the field. I screamed for help. The locals from adjacent areas rushed in and later we informed the police and Das’ family members. His body was lying beside a pond with deep head injury, probably from a bamboo stick, that was left next to him and had dry traces of blood.” Also Read – Bengal civic volunteer dies in road mishap on national highwayLocals and Das’ family members demanded immediate arrests of the culprits. Local Trinamool leader and karmadhakshya of South Dinajpur Zilla Parishad, Shyamal Saha said: “Harihar Das was an active Trinamool worker and a popular face of the area. He had close association with the party workers and locals. He also had a lot of responsibilities for the upcoming polls. The locals want quick action and have also demonstrated before the police regarding the same.” A large contingent of police force has been deployed in the area to maintain the law and order situation.last_img read more

first_img18Oct Rep. Lucido bill would charge bottled water operators a fee in Michigan Categories: Lucido News Companies bottling drinking water from Michigan sources would face a per-gallon fee under legislation introduced this week by state Rep. Peter Lucido.The 5-cent per gallon fee would help compensate the state for the loss and sale of one of its most treasured natural resources, Lucido said.“It’s not fair that these out-of-state and out-of-country corporations can swoop in, take millions of gallons of our groundwater, and sell it for a profit. They’re basically poaching our water,” Lucido, of Shelby Township, said of his legislation. “Why are we giving away our resources for free? Our state and its citizens deserve some compensation when companies are making a financial killing off our water – a resource they’re getting for practically nothing.”Lucido’s bill relates only to water used for drinking water by bottling companies. It would not apply to water withdrawn and sprinkled back into the ground.Revenue from the fee would be restricted for use on infrastructure improvements throughout Michigan.“The funds would go directly to upgrading aging infrastructure, like the municipal sewer systems that overflow and dump sewage into Lake St. Clair,” Lucido said. “We need to preserve, protect and repair our sewer and water systems, and this will provide a fitting funding source.”According to the Michigan Department of Environmental Quality, Nestle draws approximately 1.1 million gallons of water a day from its four pumping locations in Michigan. Lucido said a 5-cent per gallon fee would amount to $55,000 a day, or more than $20 million a year.House Bill 5133 has been referred to the House Natural Resources Committee.###last_img read more

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